AMPK Activator – 90 Vegetarian Capsules
AMPK Activator is an oral formula that turns on AMPK (adenosine monophosphate-activated protein kinase), an enzyme that serves as the body’s master regulating switch. Increased AMPK activity helps to revitalize aging cells, promote mitochondrial production, and inhibit multiple damaging factors associated with aging. But despite all of the scientific research, supplemental support for youthful AMPK levels has been largely non-existent … until now. The clinically validated combination of ActivAMP® (Gynostemma pentaphyllum) and rose hip plant extracts, provides nutrient support for youthful AMPK levels.
Benefits at a Glance
- Turns on master switch that revitalizes aging cells
- Promotes mitochondrial production
- Inhibits multiple damaging factors associated with aging
- Optimizes cellular energy production
- Revitalizing Aging Cells through AMPK Activation
Found in every cell,1,2 AMPK promotes longevity factors that have been shown to extend life span in numerous organisms.3,4 Increasing AMPK signaling “turns off” many damaging effects of aging, thus enabling cells to return to their youthful vitality.5
Life Extension® scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.
Importance of AMPK Activation
Greater AMPK activation has been shown to help target damaging factors of aging.5 Studies show increased AMPK activity supports reduced fat storage,6-8 new mitochondria production,9 and the promotion of healthy blood glucose and lipids already within normal range.4,10
Gynostemma Pentaphyllum Promotes Longevity and Fights Fat
An extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why — G. pentaphyllum promotes AMPK activation.10,11 In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference on average in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.8
Rose Hips Provides Metabolic Benefits
Trans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different downstream metabolic benefits than G. pentaphyllum.12-14 Among its many benefits, a low human equivalent dose of 56 mg daily trans-tiliroside has been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.15
Anti-Aging Discovery That Cannot be Overlooked
Scientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 8,500 published studies) has documented the critical role that activated AMPK plays in maintaining life-sustaining cellular functions.
If you’d like to meaningfully extend your healthy life span, activating your cellular AMPK is critical. This is important because in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines.
You can fight AMPK decline with regular exercise and avoiding excessive calories … but it may not be enough. Our AMPK Activator formula is a targeted way to reverse cellular depletion of the critical AMPK enzyme. Don’t waste another moment — try AMPK Activator today!
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.
- J Proteome Res. 2011 Apr 1;10(4):1690-7.
- Circ Res. 2007 Feb 16;100(3):328-41.
- J Mol Med (Berl). 2011 Jul;89(7):667-76.
- Physiol Rev. 2009 89:1025–78.
- Age (Dordr). 2014 Apr;36(2):641-63.
- Clin Sci (Lond). 2013 Apr;124(8):491-507.
- Biotechnol Lett. 2012 Sep;34(9):1607-16.
- Obesity (Silver Spring). 2014 Jan;22(1):63-71.
- Proc Natl Acad Sci USA. 2002 Dec 10;99 (25):15983-7.
- Bioorg Med Chem. 2011 Nov 1;19(21):6254-60.
- Carbohydr Polym. 2012 Jul 1;89(3):942-7.
- Diabetes Res Clin Pract. 2011 May;92(2):e41-6.
- Prev Nutr Food Sci. 2013 Jun;18(2):85-91.
- J Nutr Biochem. 2012 Jul;23(7):768-76.
- Bioorg Med Chem Lett. 2007 Jun 1;17(11):3059-64.
Life Extension AMPK Activator – 90 Vegetarian Capsules
Life Extension AMPK is an enzyme that serves as the body’s master regulating switch. It inhibits multiple damaging factors by revitalizing aging cells. Found in every cell, AMPK promotes longevity factors that have been shown to extend life span in numerous organisms. Increasing AMPK signaling “turns off” many damaging effects of aging, thus enabling cells to return to their youthful vitality.
Life Extension scientists have compiled years of research to create AMPK Activator, a specialized dual-extract formulation that supports AMPK activation for health optimization. This natural formula supports AMPK enzymatic activities required to safely support a more youthful cellular environment.
Importance of AMPK
Greater AMPK (adenosine monophosphate-activated protein kinase) activation has been shown to help target damaging factors of aging. Studies show increased AMPK activity supports reduced fat storage, new mitochondria production, and the promotion of healthy blood glucose and lipids already within normal range.
An extract of the plant Gynostemma pentaphyllum was traditionally used in Asian medicine to promote longevity and scientists now know why—G. pentaphyllum promotes AMPK activation. In one of many studies showing a wide variety of benefits, researchers documented a 1-inch reduction in abdominal circumference in overweight individuals who took 450 mg daily of G. pentaphyllum extract for 12 weeks.
Trans-tiliroside, extracted from plants such as rose hips, also boosts AMPK activation, but triggers different downstream metabolic benefits than G. pentaphyllum. Among its many benefits, a low equivalent dose of 56 mg daily trans-tiliroside has been shown by researchers in preclinical studies to promote healthy blood glucose levels and body weight already within normal range.
Anti-Aging Discovery that Cannot be Overlooked
Scientists uncovered the cell-energizing effect of AMPK in the 1970s. Since then, an exponential volume of data (over 7,500 published studies) documents the critical role that activated AMPK plays in maintaining life-sustaining cellular functions.
Those seeking to meaningfully extend their healthy life span should ensure they optimally activate their cellular AMPK. The reason this is so important is that in response to aging, excess calorie consumption, and/or low levels of physical activity, AMPK activity markedly declines.
A targeted way of reversing cellular depletion of this critical enzyme is to take the new AMPK Activator formula that comprises a dual-extract, plant-based formulation.
Frequently Asked Questions
What are Life Extension’s quality control standards?
Life Extension uses only premium quality vitamins and other ingredients. Their dedication to excellence insists that their nutritional supplements meet the highest standards and criteria.
That is why Life Extension insists on purchasing only the highest quality raw materials from all over the world, primarily from leading US, Japanese and European sources. Life Extension goes one step further by using advanced analytical methods, such as high-performance liquid chromatography and gas chromatography/mass spectrometry, to ensure their products meet label claims for potency and purity. Life Extension tests its raw materials using US Pharmacopeia and other exacting pharmaceutical assay standards.
Why are Life Extension’s nutritional supplements more advanced than other dietary supplements?
The unique ingredients included in Life Extension’s products are often years ahead of the products sold by commercial vitamin companies. Life Extension scientists analyze thousands of scientific studies every week to make sure their health-promoting formulas include the most advanced life extending ingredients in the world. The Foundation interacts with the world’s foremost gerontology researchers in order to obtain inside information about antiaging breakthroughs before these findings are published. The Life Extension Foundation funds the most advanced anti-ischemia laboratory in the world, where antioxidant vitamins, hormones, and pharmaceutical agents are used to prevent free radical induced cellular damage.
Are Life Extension vitamins natural or synthetic?
Life Extension carries a combination of natural and synthetic vitamins and supplements. Some advertising statements would have them believe that “natural” is better, but natural supplements in some instances contain impurities such as pollen and naturally occurring hormones that can cause problems for some people. Synthetic nutrients are manufactured to be chemically identical (with the exception of vitamin E) to those extracted from natural sources, and are the most pure nutrient vitamins.
What does Life Extension do to ensure the quality of its products?
They focus on three specific areas.
- Raw Materials: Unlike other supplement companies, the natural ingredients that go into Life Extension’s supplements are not chosen based on cost. Instead they are chosen based on purity (to exclude contaminants such as microbes and heavy metals), potency, and usage in successful scientific research.
- Validation of the Efficacy of Ingredients by Scientific Research: Life Extension uses ingredients and dosages that accurately replicate the most successful results obtained in scientific studies for maximum efficacy.
- Manufacturing:Naturally, Life Extension is in strict compliance with current Good Manufacturing Practice (GMP) for manufacturing, packaging, and storage.
Does the label accurately list exactly what’s in the bottle?
Yes. All active ingredients from patented, scientifically validated raw materials as well as final, finished products are verified using advanced analytical methods such as HPLC (high-performance liquid chromatography), MS (mass spectrometry), etc., to ensure each and every product accurately meets label claims in strict compliance with their demanding product specifications.
When it comes to supplements, is cost an indicator of quality?
Where Life Extension is concerned, yes. Patented materials validated in scientific studies cost more – period. In contrast with many commercial brands focused on driving up margins by using the cheapest raw materials available, Life Extension collaborates with raw material suppliers who invest in scientific validation of their ingredients, which increases material costs. With Life Extension products, you get the quality you pay for.
What are the “Other Ingredients” on the label, and why are they important?
They are inactive ingredients (excipients) that play a number of critical, essential roles in the manufacturing process including:
- Achieving uniform density for accurate dosing
- Dispersing the active ingredients evenly throughout a solid tablet, capsule, and softgel
- Protecting active ingredients from rapid inactivation due to heat and moisture
- Promoting tablet disintegration, as well as capsule and softgel dissolution
- Sustaining the release of active ingredients into the body over time
Why do some companies refer to these excipients as a threat to your health?
Claiming any product is “pure and free of excipients” can be deceptive advertising, too frequently used to draw attention away from inferior active ingredients! The right inactive ingredients used in the right way do important things… like ensuring that a tablet disintegrates in your GI tract rather than just passing through your system without benefit, or keeping a product from breaking down and being susceptible to microbes. Take Life Extension blueberry extract, for example. It contains AuroraBlue wild-harvested, Alaskan blueberries. To retain their nutritional complexity, these berries are freeze-dried and carefully milled for capsule formulation. But being a whole fruit raw material, it tends to want to reconstitute itself with moisture, which would make it a breeding ground for bacteria. So Life Extension uses a drying excipient to keep the milled blueberry material dry, so it can safely deliver its superior nutritional value compared with other, less costly blueberry extracts in most commercial formulations.
All of the excipients Life Extension uses have earned GRAS (“Generally Regarded As Safe”) status. In many cases not using them compromises final product quality! Excipients are used in nutritional supplements to ensure uniform density of complex active materials, to achieve even dispersion of active ingredients, and to promote appropriate disintegration and/or dissolution of active ingredients inside your body.
Should I be concerned about the use of stearic acid?
Stearic acid functions as a flow agent in the manufacture of quality products, and stearic acid also occurs naturally in the foods you eat. For example, four ounces of dark chocolate contain 3,625 mg of stearic acid; a cup of kidney beans contains 1,655 mg of stearic acid; an ounce of raw ground beef (grass-fed) contains 2,063 mg of stearic acid; and a half pound of lean raw turkey contains 1,642 mg of stearic acid. Even a tablespoon of allspice contains 1,513 mg of stearic acid! Life Extension supplements, on the other hand, typically contain no more than 10 mg per capsule. They always use the lowest level of magnesium stearate possible.
Should I be concerned that products with soybean oil or lecithin are a source of phytoestrogens?
While it is true that soy isoflavones are phytoestrogens, the amount in soybean oil or lecithin is so minute, the USDA lists it in foods as having zero value for isoflavones. To give you a frame of reference, Life Extension’s Ultra Natural Prostate contains 4 mg of lecithin which supplies only about 0.006 mg of soy isoflavones!
Should I be concerned with the usage of genetically modified plants (GMOs)?
Soybeans are an example of a crop that has used extensive genetic engineering to increase crop yield. The reality is that soybean oil and soy lecithin are highly processed derivatives of soy, far removed from their soy origin. Genetic modification doesn’t alter the entire plant, only a specific gene. Thus, specific molecules like soy lecithin are the same whether they come from a GMO or non-GMO soy source. However, due to their sensitivity to customer concerns, products with corn and soy-based active ingredients are in process of having the labels updated to list when soy and corn-derived active ingredients have been certified to be from non-GM food crops.
Does the gelatin used in softgels and capsules contain MSG?
Gelatin does not contain MSG, but does contain about 0.05 grams of glutamic acid in one softgel. You ingest about 120 times more glutamic acid in a serving of asparagus, cabbage or tomatoes!
What’s the difference between tablets, capsules and softgels?
Sophisticated products require sophisticated delivery systems. The best companies choose the most effective finished form based on the characteristics of the raw materials, and the desired disintegration or dissolution characteristics of the finished product and the active ingredients.
Why aren’t Life Extension products organic?
The word “organic” conveys the perception of quality to consumers. But it actually relates to foods that are grown rather than products that are formulated. Many of their scientifically validated raw materials are not produced organically. Rather, their mandate includes rigorous testing and scrupulous processing. The objective is purity, both in terms of their raw materials and finished products.
About Life Extension
Life Extension was officially incorporated in 1980, but the founders have been involved in antiaging research since the 1960’s. Life Extension’s long-range goal is to extend the healthy human lifespan.
Commitment to Scientific Research
Commercial companies have made huge profits on products such as coenzyme Q10, melatonin and DHEA, each of which was introduced to the U.S. market by Life Extension at considerable risk. Life Extension performed the research on these products, determined their validity and viability, and subsequently brought them to market based upon the strength of evidence behind them.
In the past seven years, Life Extension has funded over $21 million in research through their affiliations with such esteemed institutions as U.C. Berkeley and Mt. Sinai Medical Center. In 2004, Life Extension’s scientists were awarded a $900,000 grant to continue their pioneering work, and they collaborated with BioMarker Pharmaceuticals and scientists at the National Cancer Institute to develop new anti-aging therapies. This resulted in a recently accepted publication in the prestigious Proceedings of the National Academy of Sciences.
In addition, Life Extension has funded life span studies at the Universities of Wisconsin, California at Riverside, and Arkansas, gene transfer studies at the Gerontology Research Center in Baltimore, neurotransmitter studies to find the key to brain aging at the University of California at Berekely, and resveratrol studies BioMarker Pharmaceuticals in collaboration with Harvard Medical School and Critical Care Research.
Over 30 Years of History
Life Extension has a history of being several steps ahead of the competition, and in many cases, ahead of the mainstream medical establishment and the media in terms of uncovering and reflecting the newest science and research insights.
Life Extension’s Vision
Life Extensionists believe in taking advantage of scientific research to help slow aging and enhance their chances of living longer, healthier lives through the use of nutritional supplementation and an integrative approach to health.
The goal at Life Extension is to increase the quality and longevity of human life with science-based, “cutting edge” formulations. The unique ingredients included in Life Extension products are sometimes five to ten years ahead of the products sold by commercial vitamin companies.
Every week, Life Extension’s in-house research staff analyzes thousands of scientific studies, reviews dozens of the world’s leading peer-reviewed scientific, health, and medical journals, and interacts with leading anti-aging researchers to uncover the very latest breakthroughs as they relate to nutritional supplementation. This information is then passed on to their product development team which develops scientifically innovative, health-promoting formulations.
For over 25 years, Life Extension has developed nutritional supplements with the highest degree of quality, potency, and purity. Unlike discount supplement providers, Life Extension differentiates itself through quality, not price. Many discount products, for example, use low grade vitamin C imported from China that contains traces of arsenic, lead, and iron. Since the FDA does not believe anyone should take more than 100mg a day of vitamin C, the FDA permits the importation of this contaminated vitamin C. Many Life Extensionists take over 3,000 mg of vitamin C a day, so it is crucial that they use top-quality vitamin C that has gone through 18 purification steps to remove contaminants.
Life Extension’s complete line of nutritional supplements includes vitamins, minerals, amino acids, phyto-nutrients and standardized herbal concentrates.